Promotes healthy homocysteine levels and supports the MTHFR gene variant*

methylation support+ (quarterly)
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MTHFR variant support cardiovascular & neurological health detoxification healthy homocysteine & SAM-e levels synthesis of DNA, RNA, red blood cells, & neurotransmitters activated B vitamins + betaine
Key ingredients
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Quatrefolic® Methylfolate Riboflavin (Vitamin B2) Vitamin B6 Vitamin B12 Betaine
  • GMO-free
  • major food allergen free
  • gluten-free
  • dairy-free
  • soy-free
  • vegan
Supplement Facts
Serving Size: 3 capsules
Servings Per Container: 30
Amount Per Serving

Riboflavin (as riboflavin 5-phosphate)

50 mg

Vitamin B6 (as pyridoxal 5-phosphate)

100 mg

Folate (as Quatrefolic® (6S)-5-methyltetrahydrofolic acid, glucosamine salt)

5,000 mcg DFE

Vitamin B12 (as methylcobalamin)

2,000 mcg

Betaine anhydrous (trimethylglycine)

1,700 mg
*Daily Value (DV) not establised
Activated B vitamins + betaine optimized for absorption*
Quatrefolic® Methylfolate
Support methylation via healthy homocysteine & SAM-e levels*
Quatrefolic® methylfolate is the fully activated, glucosamine salt form of methylated folic acid (5-MTHF), for optimal absorption and utilization in the body. Folate is an essential water-soluble B vitamin (B9) that vitally supports our heart, brain, cellular energy, and synthesis of amino acids, DNA, RNA, and red blood cells. In its bioactive form, folic acid is clinically shown to support healthy homocysteine and SAM-e levels to drive optimal methylation in every cell.*
Riboflavin (Vitamin B2)
Antioxidant & cofactor for MTHFR enzyme*
Our riboflavin 5’-phosphate is the fully bioactive form of this essential water-soluble micronutrient. Riboflavin (vitamin B2) is a precursor for major coenzyme flavoproteins in the body, a required cofactor for the MTHFR enzyme, and thus, folate metabolism and methylation. In addition to antioxidant and immune functions, vitamin B2 is also required for the production of niacin, vitamin B6, red blood cells, and ATP energy from the foods we consume each day.*
Vitamin B6
Drive amino acid synthesis & folate metabolism*
Our vitamin B6 is in the bioactive pyridoxal 5’-phosphate form. This vitamin is a cofactor for 100+ enzymes in our body, particularly those essential to amino acid synthesis, energy and neurotransmitter production, antioxidant and immune function, plus protein and folate metabolism (key to methylation). Vitamin B6 helps maintain healthy homocysteine levels via conversion to cysteine, which serves as a building block for collagen, keratin, and glutathione.*
Vitamin B12
Promote ATP energy & efficient methionine cycle*
Our methylated vitamin B12 (methylcobalamin) is the bioactive form of this pivotal nutrient that is whole-body relevant. It’s required for cellular energy, plus the formation of DNA, red blood cells, neurons, neurotransmitters, and antibodies. B12 serves a complementary role with folate in the methionine cycle, as they are both essential cofactors for one-carbon metabolism, optimal homocysteine recycling to methionine, and methylation.*
Ensure homocysteine conversion & major methyl donor*
A methyl derivative of the amino acid glycine, betaine (i.e., trimethylglycine) is a critical bioactive for lipid and energy metabolism, plus osmoregulation. Betaine is most famous for being a major methyl donor in the body, as it ensures homocysteine's conversion to methionine. In fact, high-potency betaine has been clinically shown to support homocysteine reduction and methionine regeneration, ultimately driving methylation function and health.*

Expert Reviews

This is the complex I recommend for daily methylation support because it's optimized for bioactivity and efficacy.*

Madiha Saeed, M.D.
Family Medicine Physician

Methylation is the biggest silent issue when it comes to our health and longevity.

Jason Wachob
mbg Founder & Co-CEO

Methylfolate—a critical nutrient to support individuals with MTHFR gene variants*

Whitney Crouch, R.D.N., C.L.T.
Integrative Registered Dietitian

There are a number of different forms of vitamin B9, but only one—methylfolate—is biologically active.

Silvia Pisoni, Ph.D.
Reproduction and Women’s Health Global Manager, Gnosis by Lesaffre

Customer Reviews

What customers are saying about methylation support+ *
Frequently Asked Questions
Email us at  or visit our  Help Center.

How should I take methylation support+?

At what time of day should I take methylation support+?

Why would I consider or need a targeted supplement to support methylation?

What is methylation?

What's the MTHFR gene?

Can I take methylation support+ with other mindbodygreen supplements?

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Is methylation support+ vegan?


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